Research and

development

Understanding the CONFO® technology​

Many conformations of GPCRs are unstable in the absence of cytosolic signalling proteins, representing key challenges for current HTS screening efforts. ConfoBodies are small (15 kDa) and stable single domain fragments harbouring full antigen-binding capacity of the original heavy chain–only antibodies that naturally occur in camelids. ConfoBodies recognize discontinuous amino acid segments on native proteins, making them ideal tools to selectively stabilize specific conformational states of (membrane) proteins.​

Figure 2: ConfoBodies lock therapeutic targets into unique druggable conformations and reveal occluded structural features that are relevant for drug discovery.