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Confo Therapeutics

 

 

 (Senior) Scientist Structural Biology

Confo Therapeutics, a spin-off of VIB and VUB, is a drug discovery company built around a disruptive technology which enables it to address ‘undruggable’ GPCRs. The company is building a portfolio of transformative medicines in various disease areas. Confo Therapeutics is currently located on the Technology Park in Zwijnaarde/Ghent and on the VUB campus in Brussels. More information about Confo’s technology and strategy can be found on www.confotherapeutics.com .


For the expansion of our drug discovery teams in Ghent and Brussels we are currently looking for (m/f):
Senior Scientists Structural Biology
 

Confo has a unique technology which makes use of antibody fragments or “ConfoBodies” to stabilize G-protein coupled receptors (GPCRs) in a particular conformation of interest as a superior starting point for protein structure determination. Recently, Confo secured an exclusive license to the Megabody technology. Megabodies enable to produce high resolution cryo-EM structures of membrane proteins, overcoming current protein size limitations and potential preferential orientation issues in the study of GPCRs via cryo-EM.
 

  • Cloning of membrane protein plasmid constructs and expression in insect and mammalian cells using a variety of transfection and infection methods

  • Characterization of expression levels in membrane and in solubilized form using binding assays

  • Construct engineering to optimize expression and/or protein stability

  • Characterization of protein stability in solubilized form using a variety of biochemical and biophysical techniques to improve the purification process

  • Biophysical, X-ray and EM experiments to produce structural results: provide experimental structural input and support to drive NCE projects to achieve milestone goals

  • Working closely with medicinal chemists and biologist to help advance the project

  • Supervising and coaching one or more research associates

  • Leading the integrated discovery activities of projects as a core member of project teams

  • Coordination and management of drug discovery projects: in a project leader role, you will be expected to maintain focus and provide direction to the team members with clear project plans and defined timelines, maintain productive relationships with project team members and communicate progress against goals in a multidisciplinary setting:  chemistry, biology, pharmacology, and modeling.  

  • PhD or equivalent experience in a related field, with at least 3 years of experience as post-doc or in a company

  • Extensive technical skills in purification, sample preparation for and design and implementation of crystallization trials as well as demonstrated experience in crystal optimization techniques for membrane proteins

  • Demonstrated experience in sample preparation and optimization for cryo-EM studies on membrane proteins

  • Demonstrated expertise in data collection and interpretation of both X-ray crystallography and cryo-EM co-structure data to support NCE optimization

  • Experience with protein biophysical characterization ((F-)SEC, IR, thermostability) and screening (thermal shift, SPR) is a plus

  • Highly collaborative, self-motivated, team-oriented individual

  • Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timeliness are essential

     

  • You are fluent in English and can communicate research results to the team and cross-functional stakeholders across the company

 

  • A competitive compensation package with extensive benefits

  • An entrepreneurial and stimulating working environment in a growing and ambitious biotech company

  • Excellent career development opportunity, with exposure to all aspects of R&D in the company, with external collaborators and partners

     

 

Do you have the right qualifications and are you up to the challenge of joining our entrepreneurial team? Then forward a short motivation letter and your CV to .

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